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The Role of Matrix Metalloproteinases (MMPs) in Human Caries

¹ Groupe Matrice Extracellulaire et Biominéralisation (EA 2496) and
² Department of Conservative Dentistry and Endodontics, Faculté de Chirurgie Dentaire, 1 rue Maurice Arnoux, 92120 Montrouge, Université Paris 5, France; and
³ Laboratoire CRRET, CNRS UMR 7149, Université Paris XII, Créteil, France

View larger version (26K): [in a new window]   Figure 1. Domain structure of the different MMPs (from Visse and Nagase, 2003).

View larger version (135K): [in a new window]   Figure 2. Progression of caries in human dentin. Magnification, 20,000X. C, cavity; B, cariogenic bacteria; LF, lysis front; H+, bacterial acids; SCD, soft carious dentin.

View larger version (146K): [in a new window]   Figure 3. Invasion of human dentin by cariogenic bacteria located inside enlarged tubuli. Magnification, 54,000X. ITD, intertubular dentin; PD, residual peritubular dentin; LC, lumen of the canaliculi; B, cariogenic bacteria; MMP, active MMPs.