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Effects of a High-cholesterol Diet on Cell Behavior in Rat Periodontitis

Department of Oral Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan;

View larger version (117K): [in a new window]   Figure 1. Apical migration of the junctional epithelium in rat gingivae. The Cholesterol (B), Periodontitis (C), and Combination (D) groups exhibited greater apical migration of the junctional epithelium than did the Control group (A). The greatest apical migration of the junctional epithelium was found in the Combination group. CEJ, cemento-enamel junction; CT, connective tissue; JE, junctional epithelium; OE, oral epithelium. Scale bar = 20 µm.

View larger version (167K): [in a new window]   Figure 2. PCNA-positive basal cells in the junctional epithelium (A,B) and TUNEL-positive fibroblasts (C,D) in rat gingivae. PCNA-positive basal cells of junctional epithelium and TUNEL-positive periodontal ligament fibroblasts with brown-stained nuclei were found to be more numerous in the Combination group (B,D, respectively) than in the Control group (A,C, respectively) at 8 wks. AB, alveolar bone; CEJ, cemento-enamel junction; CM, cementum; JE, junctional epithelium. Scale bar = 20 µm.