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Immunomodulation with Enterotoxins for the Generation of Secretory Immunity or Tolerance: Applications for Oral Infections

¹ Department of Microbiology, Immunology, and Parasitology, and Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA, USA;
² Departments of Microbiology and Immunology and
³ Oral Biology,
⁴ The Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, 3435 Main Street/Farber 138, Buffalo, NY 14214, USA;

View larger version (41K): [in a new window]   Figure. Molecular structure of heat-labile enterotoxins. A and B polypeptides are translated from a single mRNA, with an excess of B polypeptides. The leader sequences of both allow them to be transported into the periplasm, where B subunits assemble into pentamers. A disulfide bridge spans the junction of the A1 and A2 segments of the A polypeptide, where a proteolytic nick occurs. The A2 subunit non-covalently associates with the central pore in the B pentamer.