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Biological Approaches to Bone Regeneration by Gene Therapy

University of Michigan School of Dentistry, 1011 N. University Ave., Ann Arbor, MI 48109-1078, USA; rennyf{at}umich.edu

View larger version (30K): [in a new window]   Figure. Strategies for delivering therapeutic genes to tissue sites. In vivo transduction involves direct delivery of a viral or non-viral gene therapy vector to the target tissue of interest by means of a suitable carrier matrix. Ex vivo gene therapy first requires transduction of syngeneic cells in tissue culture, followed by implantation at the regeneration site of the patient (adapted from Franceschi et al., 2004).