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The Growth Hormone Receptor Gene is Associated with Mandibular Height in a Chinese Population

J. Zhou1,2, Y. Lu1, X.H. Gao1, Y.C. Chen2, J.J. Lu2, Y.X. Bai1, Y. Shen2,3,*, and B.K. Wang1,*

1 Department of Orthodontics Faculty of Stomatology Capital, University of Medical Sciences, Beijing, 100050 P.R. China
2 National Center of Human Genome Research (Beijing), Beijing 100176 P.R. China
3 National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100005 P.R. China



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  		Figure 1. DNA sequence chromatograms of GHR exon 10 SNP I526L. PCR products purified by PCR purification kit (Millipore, USA) were used as the DNA template for cycle sequencing. Sequence analysis was performed by BigDye Terminator cycle sequencing in an ABI 3700 DNA sequencer (Applied Biosystems). A is green, C is blue, G is gold, and T is red. The white lines indicate 3 genotypes of the SNP. (a) The heterozygous genotype of AC; (b) the homozygous genotype of CC; and (c) the homozygous genotype of AA.

 


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  		Figure 2. Lateral cephalometric measurements studied. Points: articulare (Ar), basion (Ba), gonion (Go), gnathion (Gn), pogonion (Pog), pterygomaxillary fissure (PTM), menton (Me), nasion (N), sella (S), A perpendicular to palate plane (A'), PTM perpendicular to palate plane (PTM'), condylion (Co), pogonion perpendicular to mandibular plane (POG'), and articulare perpendicular to mandibular plane (Ar'). Lines and planes: cranial base length (N-S, N-Ba, N-Ar, S-Ba, S-Ar), maxillary length (A'-PTM'), mandibular ramus length (Co-Go, Ar-Go), mandibular corpus length (Go-Gn, Go-POG'), overall mandibular length (Co-Gn, Ar-Gn, Ar'-Pog'), and facial height (N-Me, S-Go).

 




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