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Myofibroblasts in Palatal Wound Healing: Prospects for the Reduction of Wound Contraction after Cleft Palate Repair

¹ Department of Orthodontics and Oral Biology, and ² Department of Tumor Immunology. Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands;

View larger version (14K): [in a new window]   Figure. The myofibroblast differentiation model. indicates a stimulation of differentiation and an inhibition of differentiation. Abbreviations: F = fibroblast; Proto-MF = proto-myofibroblast; mature MF = mature myofibroblast; PDGF = platelet-derived growth factor; TGF-ß = transforming growth factor ß; ED-A FN = ED-A (EIIIA) variant of fibronectin; GM-CSF = granulocyte/macrophage-colony-stimulating factor; IFN- = interferon-; bFGF = basic fibroblast growth factor; PGE2 = prostaglandin E2.