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Proteins in Whole Saliva during the First Year of Infancy

¹ Department of Operative Dentistry and Periodontology, Dental School, University of Regensburg, D-93042 Regensburg, Germany; and
² Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA;

View larger version (115K): [in a new window]   Figure 1. Protein profile during the first year of infancy. Whole saliva from four infants (A-D) was collected at monthly intervals and examined by SDS-PAGE; gels were stained with silver. The arrows indicate the age of first tooth emergence.

View larger version (14K): [in a new window]   Figure 2. Median concentrations of total protein (A) and serum albumin (B) from 10 infants determined at each month of age (closed circles). Error bars indicate the 25% and 75% quantiles. The curves (solid lines) were deduced by regression analysis of median concentrations of protein (r2 = 0.88) and albumin (r2 = 0.93) vs. age, respectively. Arrows indicate first tooth emergence of each respective infant.

View larger version (34K): [in a new window]   Figure 3. Expression of S-IgA, salivary -amylase, MUC5B, and MUC7 during the first year of infancy. Whole saliva was collected at monthly intervals, and expression patterns were determined by Western blotting. Sample blots from single infants are depicted for S-IgA -chain (A), -amylase (C), MUC5B (E), and MUC7 (G). The arrow indicates the age of first tooth emergence. Blots from different infants were analyzed by densitometry, and signal intensities are depicted for S-IgA blots (six infants) (B), -amylase blots (seven infants) (D), MUC5B blots (four infants) (F), and MUC7 blots (four infants) (H). Closed circles represent median signal intensities. Error bars indicate the 25% and 75% quantiles. The curves (solid lines) were deduced by regression analysis of median signal intensities of S-IgA (r2 = 0.42), -amylase (r2 = 0.71), and MUC7 (r2 = 0.94) vs. age, respectively. Arrows indicate first tooth emergence of each respective infant.

View larger version (20K): [in a new window]   Figure 4. Concentrations of MUC5B and MUC7 during the first year of infancy. Median concentrations of MUC5B (circles) and MUC7 (triangles) from nine infants were determined by ELISA after each month of age. Error bars indicate the 25% and 75% quantiles. Curves for MUC5B (solid line, r2 = 0.95) and MUC7 (dotted line, r2 = 0.86) were deduced by regression analysis of median concentrations vs. age. Arrows indicate first tooth emergence of each respective infant.