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Salivary Agglutinin/DMBT1SAG Expression is Up-regulated in the Presence of Salivary Gland Tumors

F.J. Bikker1, J.E. van der Wal2, A.J.M. Ligtenberg1,*, J. Mollenhauer3, J.M.A. de Blieck-Hogervorst1, I. van der Waal4, A. Poustka3, and A.V. Nieuw Amerongen1

1 Department of Dental Basic Sciences, Academic Centre for Dentistry Amsterdam (ACTA), Van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;
2 Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands;
3 Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany; and
4 Department of Oral & Maxillofacial Surgery and Oral Pathology, Free University medical centre (VUmc)/ACTA, Amsterdam, the Netherlands;



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  		Figure. Immunohistochemical localization of DMBT1SAG in human healthy salivary gland tissue, tumor-surrounding tissue, and salivary gland tumors. The sections were counterstained with hematoxylin/eosin. (A) Healthy parotid tissue: DMBT1SAG is localized in the ducts. (B) Parotid tumor-surrounding tissue (ACC). DMBT1SAG is localized in the intercalated ducts (icd) and serous acini (a). (C) ACC surrounding tissue (upper right side) showing strong staining of luminal content of striated ducts next to ACC (lower left side). (D) Healthy submandibular gland tissue. Serous acini (a) and demilune cells (d) were DMBT1SAG-positive. (E) Submandibular tumor-surrounding tissue (PA). DMBT1SAG is localized in the intercalated ducts and strongly present in the luminal content (lc). (F) Healthy labial tissue. DMBT1SAG is localized in the ducts, demilune cells (d), and serous acini (a). (G) ACC. No DMBT1SAG was found in ACCs. (H,I) MEC, the mucus-producing cells, were DMBT1SAG-positive (m). The epidermoid-cell and intermediate-cell components were totally negative. Moreover, the luminal content (lc) stained strongly positive (H). (J) ATC, showing no DMBT1SAG expression. (K) ACT, a minor subset of tumor cells showing DMBT1SAG expression. (L), PA. DMBT1SAG staining strongly positive in the secretory product and focally some tumor cells surrounding the secretory product.

 




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