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Therapeutic Vaccine against Streptococcus sobrinus-induced Caries

¹ Laboratory of Immunology, ICBAS-Instituto de Ciências Biomédicas de Abel Salazar, Lg. Prof. Abel Salazar 2, 4099-003 Porto,
² Instituto de Biologia Molecular e Celular, Porto,
³ Faculdade de Medicina de Coimbra-Hospitais da Universidade de Coimbra, and
⁴ Faculdade de Medicina de Coimbra (Instituto de Patologia Experimental), Coimbra, Portugal;
⁵ authors contributing equally to this work;

View larger version (15K): [in a new window]   Figure 1. Evaluation of dental caries scores on proximal (A) and sulcal (B) molar surfaces involving enamel lesions in Wistar rats sham-immunized and active- or heat-inactivated-VIP-immunized. Data show means ± SD of 10 to 12 rats per group. Statistical difference in mean score among the 3 groups was assessed by ANOVA. Multiple comparisons among groups indicated a significantly different mean score of active- or inactive-VIP-immunized in comparison with sham-immunized (p < 0.001). No differences were detected between active- and heat-inactivated-VIP-immunized groups. Fig. shows results of 1 of 3 representative independent experiments.

View larger version (10K): [in a new window]   Figure 2. Comparison among salivary levels, expressed as ELISA Units (EU), of IgA specific for VIP in sham-immunized and active- or heat-inactivated-VIP-immunized rats. Results are means ± SD of 10 to 12 Wistar rats. Statistical difference in mean score among the 3 groups was assessed by ANOVA. Multiple comparisons among groups indicated a significantly different mean score of active- or inactive-VIP-immunized in comparison with sham-immunized rats (p < 0.001). No differences were detected between active- and heat-inactivated-VIP-immunized groups. Fig. shows results of 1 of 3 representative independent experiments.