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Identification of RANKL in Osteolytic Lesions of the Facial Skeleton

¹ Dept. of Oral and Maxillofacial Surgery, National Dental Centre, 5 Second Hospital Avenue, S168938, Singapore;
² Dept. of Anatomy, National University of Singapore;
³ Dept. of Oral and Maxillofacial Surgery, National University of Singapore;
⁴ Dept. of Oral and Maxillofacial Surgery, St Bartholomew’s and the Royal London School of Medicine and Dentistry, United Kingdom; and
⁵ Eastman Institute of Oral Science, UK;

View larger version (78K): [in a new window]   Figure 1. Positive RANKL-immunoreactivity in stromal cells of ameloblastoma (A), dentigerous cyst (B), odontogenic cyst (C), and radicular cyst (D). Giant cell granuloma served as positive control (E), while the fibro-epithelial polyp served as negative control (F). Positive cells seen in the fibro-epithelial polyp are dendritic cells which are known to express RANKL. Endothelial cells in blood vessels supplying the osteolytic lesions also show positive staining to RANKL (G).

View larger version (64K): [in a new window]   Figure 2. Positive TRAP-immunoreactivity in stromal cells of ameloblastoma (A), dentigerous cyst (B), odontogenic cyst (C), and radicular cyst (D). Giant cell granuloma served as positive control (E), while the fibro-epithelial polyp served as negative control (F). TRAP-positive cells are recruited from blood vessels supplying the osteolytic lesions (G). Multinucleation of pre-osteoclasts to mature osteoclasts is demonstrated by immunofluorescence (H). Nuclei are stained red by propidium iodide, and TRAP-positive cells are stained green. In situ hybridization showing positive staining for human calcitonin receptor in two multi-nucleated cells (I) and a negatively stained control (J).