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Salivary Proteins and Cytokines in Drug-induced Gingival Overgrowth

¹ Department of Operative Dentistry and Periodontology, Dental School, University of Regensburg, 93042 Regensburg, Germany; and
² School of Dental Sciences, University of Newcastle, England;

View larger version (52K): [in a new window]   Figure 1. Overall protein composition of whole saliva resolved by SDS-PAGE and assessed by image analysis. (A) Silver stain including all individuals of the study (numbered) as well as molecular-weight standards (S), independent reference samples (B, H), and additional samples derived from individuals not included in the study (XX). Sizes of molecular weight standards (M.W.) are indicated to the left in kilodaltons (kDa). (B) UPGMA dendrogram graphically depicting the similarities between individual protein banding patterns obtained after image analysis and subsequent comparison. Patient numbers (not including 16, 21, and 25) are indicated to the right for responders (R), non-responders (N), and controls (C).

View larger version (23K): [in a new window]   Figure 2. Concentrations of total protein (A), IL-1 (B), IL-6 (C), IL-8 (D), EGF (E), NGF (F), and albumin (G) in whole saliva (WHOLE), glandular parotid (PAROTID), and submandibular-sublingual (SMSL) secretions of responders (RESPONDERS; n = 10), non-responders (NON-RESPONDERS; n = 11), and controls (CONTROLS; n = 10). Dots indicate concentrations of the individuals, the columns show the median, and error bars indicate the 25 and 75 percent quantiles.

View larger version (17K): [in a new window]   Figure 3. Dot blot of IL-6 against albumin concentrations in whole saliva of responders (RESPONDERS; n = 10), non-responders (NON-RESPONDERS; n = 11), and controls (CONTROLS; n = 10). Dashed lines indicate the detection limits of the assays. The insert shows an enlarged view of the linear correlation for controls (r2 = 0.89).