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Opg, Rank, and Rankl in Tooth Development: Co-ordination of Odontogenesis and Osteogenesis

Department of Craniofacial Development, Floor 28, Guy’s Tower, GKT Dental Institute, King’s College London, Guy’s Hospital, London Bridge, London SE1 9RT, UK;

View larger version (156K): [in a new window]   Figure 1. In situ hybridization of Opg, Rank, and Rankl expression on frontal head sections at the position of first molar tooth development. Tooth epithelium outlined in red. Scale bars: 125 µm (A-F); 300 µm (G-L); 400 µm (M-O).

View larger version (29K): [in a new window]   Figure 2. Diagrammatic representation of Opg, Rank, and Rankl expression in early tooth development and proposed interaction between RANK and RANKL. (A) Expression of Opg, Rank, and Rankl in epithelium shown in blue and in mesenchyme in red. (B) Relationship between RANKL in dentary bone mesenchymal cells and RANK and OPG in tooth germ.

View larger version (79K): [in a new window]   Figure 3. Cultured mandibular primordia explants treated with protein beads. BSA control beads (A). OPG beads, 50 ng/mL (B); 100 ng/mL (C); 200 ng/mL (D), 400 ng/mL (E). Retardation of tooth epithelium invagination observed in explants treated with 200 ng/mL (D) and 400 ng/mL (E) of OPG protein. Tooth epithelium outlined in red. Scale bar: 90 µm.

View larger version (79K): [in a new window]   Figure 4. Teeth were recovered from renal capsules after 12 days. Teeth recovered from renal capsules (A,B). (C,D) Teeth following decalcification. Arrows show high translucency in comparison with others. (E-G) Sections of teeth. E, BSA controls; F and G, examples of teeth treated with OPG. Scale bars: 100 µm (A-D); 25 µm (E-G).