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In vitro Estrogenicity of Resin Composites

Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan;

View larger version (35K): [in a new window]   Figure 1. Relative luciferase activities of eluates from cured composite disks. The bar represents the standard deviation of 3 replicates, and the differences between the samples and the negative control, D-MEM, were analyzed by ANOVA and Scheffé’s F test at a significance level of 0.05. Eluates of 6 composites showed significantly greater luciferase activity than the negative controls (*p < 0.05, shaded bars). The other specimens showed no significant differences from the control (p > 0.05, open bars). **D-MEM as negative control.

View larger version (38K): [in a new window]   Figure 2. Relative luciferase activities of the 3 estrogenic components and biphenol-A (BPA). HMBP (a) and DMPA (b) showed significantly greater luciferase activity than the negative controls at a concentration = 1 µmol/L (*p < 0.05, shaded bars). BHT (c) showed significant differences (p < 0.05) from the controls at a concentration = 50 µmol/L (*p < 0.05, shaded bars), while BPA (d) showed estrogenicity at a concentration = 100 nmol/L (*p < 0.05, shaded bars). **The negative control contained D-MEM with 0.1% dimethyl sulfoxide.

View larger version (21K): [in a new window]   Figure 3. Relationship between concentration of HMBP (a) or DMPA (b), leached after 24 hrs of immersion of cured composite disks in distilled water, and the minimum estrogenic concentrations of each chemical. HMBP eluted from 12 cured composite disks at concentrations ranging from 0.02 to 0.35 mg/L, and the values for Revolution, Spectrum, Surefil, and Charisma exceeded the minimum estrogenic concentration (a, shaded bars). DMPA leached from Charisma and Flowline at 0.31 and 0.28 mg/L, respectively, which exceeded the minimum estrogenic concentrations (b).