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Differential Expression of RANKL and Osteoprotegerin in Gingival Crevicular Fluid of Patients with Periodontitis

¹ Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan; and
² Department of Periodontology, Matsumoto Dental University School of Dentistry, Shiojiri, Nagano 399-0781, Japan;

View larger version (23K): [in a new window]   Figure. Plots depicting RANKL (pg/µL; A) and OPG (pg/µL; B) concentrations and RANKL/OPG ratio (C) in the subgingival crevices of control, mild, moderate, and severely diseased subjects. The content of RANKL in the GCF was determined by an ELISA, and that of OPG also by ELISA, a commercially available one. To improve the display of data in the Fig., we made the scales in ‘A’ and ‘B’ the same. Data are expressed as the mean ± SEM. Control (28), mild (27), moderate (58), and severe (47) subjects were analyzed. * P < 0.05, ** P < 0.01, *** P < 0.005 (compared with control)), and # P < 0.05 as indicated by the brackets.