HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Werner, H. Articles by Katz, J. Search for Related Content PubMed PubMed Citation Articles by Werner, H. Articles by Katz, J.

The Emerging Role of the Insulin-like Growth Factors in Oral Biology

¹ Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; and
² Division of Oral Medicine, Department of Oral/Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, PO Box 100416, Gainesville, FL 32610-0416, USA;

View larger version (23K): [in a new window]   Figure. The IGF system. The IGF system is comprised of 3 ligands (insulin, IGF-I, and IGF-II), 3 receptors (insulin, IGF-I, and IGF-II/mannose 6-phosphate receptors), and at least 6 IGF-binding proteins (IGFBP1-6). Naturally occurring hybrid receptors have been described in which an insulin /ß hemireceptor is linked to an IGF-I /ß hemireceptor. The black area in the receptor cytoplasmic region denotes the tyrosine kinase domain. The IGF-II/mannose 6-phosphate receptor is a single-chain polypeptide composed of 15 repeat sequences and a short cytoplasmic domain. IGF-I and IGF-II circulate in blood and extracellular space linked to a family of binding proteins. IGFBP3 is the most abundant BP in serum, and it appears as a ternary complex that includes the ligand and an acid-labile subunit (ALS). IGFBP proteases have been described that cleave IGFBPs, thus modulating the bioavailability of IGF ligands. IGFBP6 exhibits a particularly high affinity for IGF-II.