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Figure 3. Lengths of mouse mandibular first molar tooth cementum. These measurements are of mesial and distal lingual roots of three lines of mice genetically engineered to produce alterations in the growth hormone (GH) axis. Data are of cellular cementum lengths, acellular cementum lengths, and total cementum lengths (cellular+acellular). (A) Cementum lengths of bovine GH (MT-bGH) mice, of either giant mutant (GHXs) or wild-type (Wt) phenotype (both roots, n = 10). (B) Cementum lengths of antagonist MT-bGH (bGH-G119K) mice, of either dwarf mutant (GHAnt) or Wt phenotype (both roots, n = 10). (C) Cementum lengths of GH receptor-deleted (GHR-KO) mice, either Wt mice (mesial roots, n = 10; distal roots, n = 8), heterozygous (Het) mice (mesial roots, n = 8; distal roots, n = 9), or homozygous dwarf (KO) mice (mesial roots, n = 8; distal roots, n = 7). The lengths were quantified by morphometric analysis of images of stained sections of mouse molar teeth by comparison with images of a 2.00-mm scalar. All mice were 45 days old. All lengths are presented as mean ± 2SEM in mm2. *p < 0.05; **p < 0.01; ***p < 0.001; one-way ANOVA
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to * is cellular cementum; area C is apical cellular cementum. (B,C) Sections of mesial tooth roots of littermate mice of a GH excess (giant) mice line. (B) Wild-type (Wt) phenotype. (C) Giant (GHXs) phenotype. (D,E) Sections of mesial tooth roots of littermate mice of a GH antagonist excess (dwarf) mice line. (D) Wild-type (Wt) phenotype. (E) Dwarf (GHAnt) phenotype. (F-H) Sections of mesial tooth roots of littermate mice of a GH receptor-deleted (GHR-KO) (dwarf) mice line. (F) Wild-type (Wt) phenotype. (G) Heterozygous (Het) for the GHR-KO mutation. (H) Dwarf (KO) phenotype.