This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Rabie, A.B.M. Articles by Harley, V.R. Search for Related Content PubMed PubMed Citation Social Bookmarking                   What's this?

Forward Mandibular Positioning Up-regulates SOX9 and Type II Collagen Expression in the Glenoid Fossa

¹ Hard tissue biology and repair research group and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China; and
² Prince Henry’s Institute, Melbourne, Australia;

View larger version (144K): [in this window] [in a new window]   Figure 1. Photomicrographs showing the expression of type II collagen at 38 days of natural growth in the anterior (A), middle (M), and posterior (P) regions of glenoid fossa (G), as well as the middle and posterior regions of the mandibular condyle (C), indicated by brown stains in the extracellular matrix of the hypertrophic layer (H) and in the chondrocytes.

View larger version (148K): [in this window] [in a new window]   Figure 2. Immunostaining of SOX9 and type II collagen in glenoid fossa. Photomicrographs showing the expression of SOX9 (A,B), indicated by brown stains, in proliferative (P) and hypertrophic (H) cells and type II collagen (C–F), indicated by brown stains of the chondrocytes and in the extracellular matrix (H). (A) Natural growth, day 38; (B) mandibular forward positioning, day 3 (38 days of natural growth); (C) natural growth, day 38; (D) mandibular advancement, day 3 (38 days of natural growth); (E) natural growth, day 52; and (F) mandibular forward positioning, day 17 (52 days of natural growth).

View larger version (18K): [in this window] [in a new window]   Figure 3. Graphs show the temporal patterns of expression of SOX9 and type II collagen in the anterior, middle, and posterior regions of the glenoid fossa during natural growth (A,B) and forward mandibular positioning (C,D). (A) Expression of SOX9 in the anterior, middle, and posterior regions during natural growth. (B) Expression of type II collagen in the anterior, middle, and posterior regions during natural growth. (C) Expression of SOX9 in the posterior region of the glenoid fossa during forward mandibular positioning and natural growth (n = 40). (D) Expression of type II collagen in the posterior region of the glenoid fossa during forward mandibular positioning and natural growth (n = 40). *p < 0.05; **p < 0.01; ***p < 0.0001.

View larger version (44K): [in this window] [in a new window]   Figure 4. Proposed model explaining how forward mandibular positioning could affect the gene expression of SOX9 and type II collagen.

CiteULike

Connotea

Del.icio.us

Digg

Reddit

Technorati