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Evidence of a Substantial Genetic Basis for IgG2 Levels in Families with Aggressive Periodontitis

S.R. Diehl1,*, T. Wu1, J.A. Burmeister2, J.V. Califano2, C.N. Brooks2, J.G. Tew2, and H.A. Schenkein2

1 Center for Pharmacogenomics and Complex Disease Research, New Jersey Dental School, UMDNJ, 185 South Orange Ave, MSB C-636, Newark, NJ 07101-1709; and
2 Clinical Research Center for Periodontal Diseases, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298;



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  		Figure 1. Antibody levels by age, race, sex, and smoking status. (A) IgG2 antibody levels (µg/mL) predicted at different ages by the linear equation modeled in the variance component analysis based on all subjects combined (periodontally healthy and diseased). Predicted IgG2 levels are presented separately for black and white races, females and males, and smokers and non-smokers. Points on the lines represent predicted values for individual subjects within the group represented by the line, plotted at the subject’s actual age at the time of IgG2 measurement. The lines are curved because we included the statistically significant age-squared term in the model. (B) IgG2 levels (µg/mL) in localized AgP subjects.

 


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  		Figure 2. Covariates explain less than 20% of IgG2 variance. Comparison of actual values measured for IgG2 for individual subjects within the black female non-smoker group (points) with the values predicted by the variance component model on the solid line.

 




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