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Vanilloid Receptor Expression in the Rat Tongue and Palate

¹ Department of Oral Anatomy and Cell Biology, and
² Department of Fixed Prosthodontics, Graduate School of Dental Science, Kyushu University, Fukuoka 812-8582, Japan;

View larger version (24K): [in a new window]   Figure 1. Schematic diagrams of the hard palate and tongue of the rat. Squares indicate areas with intense VR1 immunoreactivity.

View larger version (21K): [in a new window]   Figure 2. VR1 expression by RT-PCR in the circumvallate papillae (lanes 1, 2), foliate papillae (lanes 3, 4), and palatal rugae (lanes 5, 6). Lanes 2, 4, and 6 are negative controls with template, but no reverse transcriptase. Lane 7 is positive dorsal root ganglion control.

View larger version (165K): [in a new window]   Figure 3. Photomicrographs showing taste papillae. Rich VR1-immunoreactive fibers in taste papillae: fungiform (A,B), circumvallate (D,E,F), foliate (G,H,I,J), and Geschmacksstreifen (K,L). CGRP immunoreactivities in fungiform papilla (C). Many VR1-positive fibers surround the furrows of the circumvallate and foliate papillae, forming plexuses (double arrows). Arrowheads indicate nerve fibers penetrating the apical and trench wall epithelia. Occasional fibers enter taste buds or pores (arrows). Conspicuous VR1-positive nerves in the boundary area just above the taste buds (F,I). Low-power micrographs showing VR1 expression in the dorsal (A,D), lateral (G), and ventral epithelium (K) (asterisks). Scale bars: A,D,G,K = 50 µm; B, C,E,F,H,I,J,L = 20 µm.

View larger version (112K): [in a new window]   Figure 4. Photomicrographs showing VR1-immunoreactivity in the palatal intermolar rugae. Note the intense labeling in the summit of the rugal epithelium, where there are no VR1 nerves (A,B). The rich nerve supply with PGP (C) or CGRP (D) immunoreactivity to the rugae in a serial section of A. Elimination of staining with antibody pre-adsorbed with antigenic peptide (E). Scale bars: 50 µm.