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Altered pH Regulation During Enamel Development in the Cystic Fibrosis Mouse Incisor

W. Sui, C. Boyd, and J.T. Wright*

Department of Pediatric Dentistry, Brauer Hall CB 7450, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7450, USA;



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  		Figure 1. Mouse incisor pH. (A) Normal incisor stained with pH indicator showing a near-neutral pH during the secretory stage (S), that becomes acidic during the transition stage (T) and modulates between neutral and acidic pH during the maturation stage (M) (2 yellow bands and 2 light green bands [neutral bands designated with *]). (B) CF incisor stained with pH indicator shows a neutral secretory-stage pH and acidic transitional stage, while the maturation-stage zone appeared to be yellow, indicating a sustained lower pH. (C) Higher magnification of the CF incisor maturation-stage enamel showed multiple fine pigmented and unpigmented horizontal strips decorating the surface.

 


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  		Figure 2. Mouse incisor GBHA staining. (A) Normal incisor stained with GBHA showed minimal staining in the secretory stage (S) enamel, no staining in the transition stage (T), and a modulation during the maturation stage (2 red bands designated with arrows). (B) CF incisor stained with GBHA showed similar secretory (S) and transitional (T) stage staining, but showed no visible staining in the maturation-stage enamel (M).

 


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  		Figure 3. pH regulation by ameloblasts. Schematic diagram illustrating the multiple ion regulators potentially functioning in ameloblasts to regulate pH of the enamel matrix. CFTR regulates the electrogenic Na:HCO3- co-transporter and Cl-/HCO3- exchangers to deliver HCO3- into the developing enamel layer.

 




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