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Implant Surface Roughness Affects Osteoblast Gene Expression

N402, Dows Institute for Dental Research and the Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, IA 52242;

View larger version (45K): [in a new window]   Figure 1. Design of Real Time primers for Cbfa1 and bone sialoprotein.

View larger version (98K): [in a new window]   Figure 2. SEM of the sandblasted rough (A) and 600-grit grooved (B) surface structures of the prepared titanium discs. Magnification, 1000x; bar = 10 µm.

View larger version (89K): [in a new window]   Figure 3. Osteoblast cultures mineralize significantly more (P < 0.05) on rough as compared with grooved implant surfaces, as demonstrated by Alizarin Red S staining (A). Reduction in mineralization was not due to loss of cell attachment (B), or differences in rates of cell proliferation (C). n = 5/group; mean ± SD.

View larger version (16K): [in a new window]   Figure 4. Cbfa1 gene expression is significantly (P < 0.05) increased in UMR (A) and RCOB (B) osteoblast culture models grown on roughened implant surface microtopographies as demonstrated with Real Time PCR analysis. BSPII gene expression increased in UMR cultures (C), but was reduced in RCOB cells (D) cultured on rough as compared with grooved implant surfaces. n = 9/group; mean ± SD.