JDR JDR Most Read Articles
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (33)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schneider, G.B.
Right arrow Articles by Stanford, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schneider, G.B.
Right arrow Articles by Stanford, C.

Implant Surface Roughness Affects Osteoblast Gene Expression

G.B. Schneider*, H. Perinpanayagam, M. Clegg, R. Zaharias, D. Seabold, J. Keller, and C. Stanford

N402, Dows Institute for Dental Research and the Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, IA 52242;



View larger version (45K):

[in a new window]
 
Figure 1. Design of Real Time primers for Cbfa1 and bone sialoprotein.

 


View larger version (98K):

[in a new window]
 
Figure 2. SEM of the sandblasted rough (A) and 600-grit grooved (B) surface structures of the prepared titanium discs. Magnification, 1000x; bar = 10 µm.

 




View larger version (89K):

[in a new window]
 
Figure 3. Osteoblast cultures mineralize significantly more (P < 0.05) on rough as compared with grooved implant surfaces, as demonstrated by Alizarin Red S staining (A). Reduction in mineralization was not due to loss of cell attachment (B), or differences in rates of cell proliferation (C). n = 5/group; mean ± SD.

 


View larger version (16K):

[in a new window]
 
Figure 4. Cbfa1 gene expression is significantly (P < 0.05) increased in UMR (A) and RCOB (B) osteoblast culture models grown on roughened implant surface microtopographies as demonstrated with Real Time PCR analysis. BSPII gene expression increased in UMR cultures (C), but was reduced in RCOB cells (D) cultured on rough as compared with grooved implant surfaces. n = 9/group; mean ± SD.

 





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
Copyright © 2003 Institutional Access Guidelines