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The Effect of High Sugar Intake on the Development of Periradicular Lesions in Rats with Type 2 Diabetes

¹ Departments of Endodontics and
² Pathology, School of Dentistry, Aichi-Gakuin University, 2-11 Suemori-dori, Chikusa-ku, Nagoya 464-8651, Aichi, Japan; and
³ Department of Stomatology, University of California, San Francisco, CA 94143, USA;

View larger version (75K): [in this window] [in a new window]   Figure 1. Blood glucose level and total leukocyte count. (a,b) At all time points, the blood glucose level was higher in groups C and D than in groups A and B (n = 5, p 0.01). (c) The rats in groups A and B had significantly more leukocytes than those in groups C and D at all experimental periods (n = 5, p 0.01).

View larger version (88K): [in this window] [in a new window]   Figure 2. Histologic findings at 2 wks. (a) In group A, necrosis (black arrow) was confined to the upper part of the pulpal tissue. Inflammatory cell infiltration was observed in the lower part of the pulpal tissue, and alveolar bone resorption was seen in the periradicular tissue. (b) In group C, necrosis (black arrow) was confined to the upper part of the pulpal tissue. Inflammatory cell infiltration and alveolar bone resorption were observed in the periradicular tissue. (c) In group D, the pulpal tissue was almost completely necrotic (black arrow), and inflammatory cell infiltration and alveolar bone resorption were found. (a-c) Hematoxylin-eosin; original magnification, x20.

View larger version (91K): [in this window] [in a new window]   Figure 3. Histologic findings at 4 wks. In groups A (a) and C (b), necrosis was observed in the entire pulpal tissue, and alveolar bone resorption (black arrow) was present. (c) In group D, an abscess (black arrow) around the root apex was present, and alveolar bone resorption was seen in the roots, root apex, and the root furcation. (a-c) Hematoxylin-eosin stain; original magnification, x20.

View larger version (26K): [in this window] [in a new window]   Figure 4. Histometric findings. The periradicular lesions were significantly larger in group D than in the three other groups at both 2 and 4 wks (n = 5, p < 0.01).

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