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Journal of Dental Research, Vol. 82, No. 12, 993-997 (2003)
DOI: 10.1177/154405910308201211

Central Muscarinic Receptors Signal Pilocarpine-induced Salivation

A.C.T. Takakura, T. S. Moreira, S.C. Laitano, L.A. De Luca, Jr., A. Renzi and J. V. Menani*

Department of Physiology and Pathology, School of Dentistry, Paulista State University-UNESP, Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil;


Figure 1
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  		Figure 1. Salivation (mg/7 min) induced by ip injection of pilocarpine (4 µmol/kg of body weight) in rats pre-treated with (A) icv atropine methyl bromide (ATR: 2, 4, 8, and 16 nmol/1 µL) (open bars) or saline (filled bars) and (B) ip atropine methyl bromide (ATR: 2, 4, 8, and 16 nmol/0.1 mL) (open bars) or saline (filled bars). The results are represented as means + SEM. n = number of rats. *Significantly different from saline + pilocarpine (Student-Newman-Keuls test, p < 0.05).

 

Figure 2
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  		Figure 2. Changes in mean arterial pressure (MAP) and heart rate (HR) produced by iv injection of acetylcholine (8 nmol/0.1 mL/rat) in rats pre-treated with icv atropine methyl bromide (ATR: 4, 8, and 16 nmol/1 µL) (open bars) or saline (filled bars). The results are represented as means + SEM. n = number of rats.

 

Figure 3
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  		Figure 3. Changes in mean arterial pressure (MAP) and heart rate (HR) produced by iv injection of acetylcholine (8 nmol/0.1 mL/rat) in rats pre-treated with iv atropine methyl bromide (ATR: 4, 8, and 16 nmol/0.1 mL/rat) (open bars) or saline (filled bars). The results are represented as means + SEM. n = number of rats. *Significantly different from saline + acetylcholine (Student-Newman-Keuls test, p < 0.05).

 

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