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Survivin, a Potential Early Predictor of Tumor Progression in the Oral Mucosa

¹ Institute of Dental Sciences, Faculty of Medicine, University of Ancona, Ancona, Italy;
² Department of Biomorphological and Functional Sciences, Pathology Unit, Faculty of Medicine, University of Naples Federico II, Naples, Italy;
³ Institute of Dental Sciences, University of Catania, Catania, Italy;
⁴ Department of Dental Sciences and Maxillofacial Surgery, Faculty of Medicine, University of Naples Federico II, Naples, Italy;
⁵ Department of Oral Pathology, Faculty of Dentistry, Hiroshima University, Hiroshima, Japan; and
⁶ Department of Cancer & Biology and the Cancer Center, Medical School, University of Massachusetts, Worcester, USA;

View larger version (130K): [in this window] [in a new window]   Figure. Immunohistochemical determination of survivin in oral epithelium. (A) Normal oral mucosa showing low levels of survivin expression in sporadic cells of basal and parabasal layers (150x). (B) Oral leukoplakia with no detectable survivin expression (250x). (C) Severe/moderate oral dysplasia showing cytoplasmic expression of survivin (400x). (D) OSCC with moderate grade of differentiation showing strong cytoplasmic positivity for survivin (250x). 50x. Bar = 50 µm.

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