This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Dale, B. A. Search for Related Content PubMed PubMed Citation Social Bookmarking                   What's this?

Fascination with Epithelia: Architecture, Proteins, and Functions

Dept. of Oral Biology, Box 357132, University of Washington, Seattle, WA 98195-7132; bdale{at}u.washington.edu

View larger version (60K): [in this window] [in a new window]   Figure 1. Evolution in the understanding of epithelial structure and function. Changes over time are indicated left to right for the way in which epithelium has been considered and the types of methods used for investigation.

View larger version (67K): [in this window] [in a new window]   Figure 2. The complex epithelial antimicrobial barrier. The physical barrier of the epithelium is enhanced by differentiation. The epithelium also signals other cell types in response to bacterial exposure. Epithelial antimicrobial peptides have direct action on bacteria and also signal immature dendritic cells, macrophages, and T-cells, which then further up-regulate epithelial responses. Chemokines (i.e., IL-8), cytokines, and adhesion molecules (i.e., intercellular adhesion molecule-1) are expressed by keratinocytes and Langerhans cells (purple). Langerhans cells also migrate out of the tissue for antigen presentation and to elicit the acquired immune response. Adapted from Dale, 2002.

CiteULike

Connotea

Del.icio.us

Digg

Reddit

Technorati