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Aging and Secretory Reserve Capacity of Major Salivary Glands

¹ University of Michigan School of Dentistry, Department of Cariology, Restorative Sciences, and Endodontics, Ann Arbor;
² New York University College of Dentistry, Department of Oral Medicine, and Bluestone Center for Clinical Research, 421 First Avenue, 2nd Floor, New York, NY 10010-4086, USA;

View larger version (18K): [in a new window]   Figure 1. Stimulated submandibular/sublingual flow rates over a six-hour period of time in a healthy 24-year-old male after IV glycopyrrolate (4.0 µg/kg) and placebo (D5W). A, Start of suppression; B, Maximum salivary reduction; C, Recovery; A - C, Time of suppression.

View larger version (18K): [in a new window]   Figure 2. Stimulated parotid flow rates over a six-hour period of time in 18 healthy young (ages 20-38) and 18 healthy older (ages 60-77) adults after IV glycopyrrolate administration. Results expressed as mean values ± SEM.