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Journal of Dental Research, Vol. 82, No. 10, 791-795 (2003)
DOI: 10.1177/154405910308201006

Parathyroid Hormone Protects against Periodontitis-associated Bone Loss

S.P. Barros1,*, M.A.D. Silva1, M.J. Somerman2,3 and F.H. Nociti, Jr.2,4

1 Department of Morphology, Division of Histology, School of Dentistry at Piracicaba, University of Campinas, Av. Limeria, 901, 13414-903 Piracicaba SP, Brazil;
2 Department of Periodontics, School of Dentistry, University of Washington, Seattle;
3 Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, Ann Arbor; and
4 Department of Prosthodontics/Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, University of Campinas, Brazil;


Figure 1
Figure 1
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  		Figure 1. Histological aspect of molar furcation area for the different experimental groups. (A) Ligated tooth from the placebo group. The extension of the PL area indicates bone loss due to induction of periodontitis. (B) Unligated tooth from the placebo group. (C) Ligated tooth from a PTH-treated animal. Dentin (D), periodontal ligament area (PL), alveolar bone (B). Scale bar represents 0.25 mm. (D) Mean ± standard deviation of the area between bone crest and cementum surface (mm2) in the furcation area of ligated teeth from PTH-treated animals in comparison with the ligated and unligated teeth from the placebo group (*p < 0.05). Note: Similar findings were observed in sections obtained from unligated teeth regardless of treatment (PTH vs. placebo). N = 10/group.

 

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  		Figure 2. Histological aspects of the furcation area. (A) Low magnification of a ligated molar from the placebo-treated group. (B) Higher magnification: Osteoclasts and resorption pits can be observed (OC/arrows) in the bone area. (C) Periodontal ligament region: Disarrangement of periodontal ligament fibers can be observed. Periodontal ligament (PL), alveolar bone (B), osteoclast (OC). Scale bars: A, 0.2 mm; B, 0.1 mm; C, 0.05 mm.

 

Figure 3
Figure 3
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  		Figure 3. Histological aspects of marginal gingival tissue. (A) Section around a ligated molar from the placebo-treated group, showing intense inflammatory infiltrate, consisting mainly of neutrophils. (B) Section around a ligated molar from a PTH-treated animal, showing limited inflammatory cell infiltrate. Scale bar represents 0. 05 mm. (C) Total number of inflammatory cells found in the marginal gingival tissue around molars obtained from unligated and ligated teeth from the placebo group and ligated teeth from the PTH-treated group (*p < 0.05). N = 10/group.

 

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