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Gene Expression Profiling of Ameloblastoma and Human Tooth Germ by Means of a cDNA Microarray

¹ Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, FIN-20520 Turku, Finland;
² Department of Medical Genetics, Haartman Institute and Helsinki University Central Hospital, FIN-00014 University of Helsinki, Finland; and
³ Haartman Institute, Department of Pathology, FIN-00014 University of Helsinki, Finland;

View larger version (54K): [in this window] [in a new window]   Figure 1. Gene expression profile in ameloblastoma. (A) Distribution of gene expression level in ameloblastoma by means of cDNA microarray visualized with TreeView. Ameloblastomas (from 1 to 8) are shown in columns, and genes are shown in rows. Genes showing differences in expression level are displayed in descending order, from underexpressed genes (green) to overexpressed genes (red). (B) Comparison of gene expression levels by means of scatterplot of log-intensities. Comparison between two normal tooth germ samples hybridized in separate experiments (i). Comparison between same ameloblastomas in separate experiments (ii), and between normal tooth germ and ameloblastoma (iii). Each point represents one of the 588 genes. X-axis represents gene expression level in one experiment. Y-axis represents gene expression level in second experiment. (C) Comparison between real-time RT-PCR and cDNA array results is plotted pairwise on successive rows for 6 genes in 5 ameloblastomas, respectively.

View larger version (42K): [in this window] [in a new window]   Figure 2. cDNA array images after hybridization of normal tooth germ (reference, R) and ameloblastomas (number of cases: from 1 to 8). Two genes are marked for visual identification in each experiment. Large arrows indicate a gene (FOS) overexpressed compared with reference (R); small arrows indicate a gene (ARHGAP4) underexpressed compared with reference (R).

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