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Journal of Dental Research, Vol. 81, No. 7,
501-504 (2002)
DOI: 10.1177/154405910208100714
Quantitative Trait Loci on Chromosomes 10 and 11 Influencing Mandible Size of SMXA RI Mouse Strains
A. Dohmoto,
K. Shimizu,
Y. Asada and
T. Maeda*
Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan;
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Figure 1. Measurement landmarks on the mandible. Outline of a mouse mandible showing the 2 landmark points that were measured. The point located at the anterior region is the menton and that at the posterior region is the gonion.
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Figure 2. Distribution of the mandible sizes in 21 of the SMXA RI strains and 2 parental strains (SM/J and A/J). The bars colored black, white, and gray indicate data from the means of males (n = 5), females (n = 5), and males and females (n = 10), respectively. The histogram is arranged in order of increasing mean sizes. The data represent means ± SD. The mandible size in the Fig. is scaled up to double the actual size (see MATERIALS & METHODS).
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Figure 3. Plot of the LOD scores on chromosome 11 (A) and chromosome 10 (B). Shown in solid lines are the QTL data from males, and in the dotted lines are data from females. The vertical lines represented by the numeric values of 2.2, 2.3, and 4.0 indicate the suggestive levels in males, in females, and the significant levels in females, respectively. The top of the Fig. represents the centromere, and the bottom of the Fig. represents the telomere along the markers. Two significant QTLs in female and 2 suggestive QTLs are detected in the proximal region of chromosome 11 (A). In the distal region of chromosome 10, the suggestive QTL is detected in females (B). The map position in this Fig. represents the distance between the centromere and the marker that is near the peak LOD score.
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Figure 4. Strain distribution pattern (SDP) of chromosome 10 (A) and chromosome 11 (B) around the peak LOD scores. Genetic and microsatellite marker loci around the peak LOD scores are listed at the left side. Each column represents a genotype identified in each SMXA RI strain mouse. The black box indicates the A/J alleles, the white box indicates the SM/J allele, and the gray box indicates that the genotype was not determined.
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