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Interferon-gamma Deficiency Attenuates Local P. gingivalis-induced Inflammation

¹ Department of Periodontology and
² Department of Oral Biology, Faculty of Dental Medicine, Hadassah and Hebrew University Medical Centers, PO Box 12272, Jerusalem 91120, Israel;

View larger version (25K): [in a new window]   Figure 1. Levels of leukocytes (A), TNF- (B), IL-1ß (C), and IL-10 (D) in the chambers of IFN-/- and IFN+/+ mice following P. gingivalis challenge. Mice (n = 6, each group) were challenged with P. gingivalis, and chamber exudates were harvested for analysis after 2 and 24 hrs. Results are expressed as mean ± standard error. Significant differences between IFN-/- and IFN+/+ groups at the same time point (p < 0.05) are indicated by an asterisk.

View larger version (20K): [in a new window]   Figure 2. Levels of TNF-, IL-10, and IFN in the chambers of IFN-/- mice following local delivery of the IFN gene. The IFN gene or vector alone (n = 6, each group) was injected into the chambers, followed, two days later, by the intra-chamber P. gingivalis challenge. Chamber exudates were harvested after 4 hrs for analysis. Results are expressed as mean ± standard error. Significant differences between IFN gene and vector groups (p < 0.05) are indicated by an asterisk.

View larger version (16K): [in a new window]   Figure 3. Levels of anti-P. gingivalis IgG1 and IgG2a in the chambers of immunized IFN-/- and IFN+/+ mice (n = 6, each group). The animals were immunized by two consecutive injections of heat-killed P. gingivalis in Alum adjuvant, followed, 11 days later, by intra-chamber challenge of P. gingivalis. Exudates were harvested 24 hrs post-challenge. Significant difference between IFN-/- and IFN+/+ groups (p < 0.05) are indicated by an asterisk.