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P. gingivalis-specific T-cell Lines Produce Th1 and Th2 Cytokines

Immunopathology Laboratory, Oral Biology and Pathology, School of Dentistry, The University of Queensland, Brisbane 4072, Australia;

View larger version (35K): [in this window] [in a new window]   Figure 1. Cytokine expression by P. gingivalis-specific T-cell lines in response to homologous outer membrane antigens presented by mononuclear cells. (A) Mean (± standard error of the mean) % IL-4+, IFN-gamma+, and IL-10+ CD4 cells in P. gingivalis-specific T-cell lines established following presentation of P. gingivalis outer membrane antigens by peripheral blood mononuclear cells (PBMC) (n = 16) and EBV-transformed B-cells (LCL) (n = 15), respectively. (B) Mean (± standard error of the mean) % IL-4+, IFN-gamma+, and IL-10+ CD8 cells in P. gingivalis-specific T-cell lines established following presentation of P. gingivalis outer membrane antigens by peripheral blood mononuclear cells (PBMC) (n = 16) and EBV-transformed B-cells (LCL) (n = 15), respectively.

View larger version (79K): [in this window] [in a new window]   Figure 2. Cytokine expression by specific T-cell lines in response to P. gingivalis outer membrane antigens presented by other antigen-presenting cells. (A) Mean (± standard error of the mean) % IL-4+, IFN-gamma+, and IL-10+ CD4 cells in P. gingivalis-specific T-cell lines established following presentation of P. gingivalis outer membrane antigens by B-cells (n = 8), monocytes (n = 10), monocyte-derived dendritic cells (MoDC) (n = 8), and peripheral blood (PBDC) (n = 8) dendritic cells, respectively. (B) Mean (± standard error of the mean) % IL-4+, IFN-gamma+, and IL-10+ CD8 cells in P. gingivalis-specific T-cell lines established following presentation of P. gingivalis outer membrane antigens by B-cells (n = 8), monocytes (n = 10), monocyte-derived dendritic cells (MoDC) (n = 8), and peripheral blood (PBDC) (n = 8) dendritic cells, respectively.

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