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The Role of MSX1 in Human Tooth Agenesis

Department of Orthodontics, University of Iowa, 140 EMRB, Iowa City, IA 52242, USA;

View larger version (28K): [in a new window]   Figure 1. Number of missing teeth per individual, not including 3rd molar agenesis.

View larger version (31K): [in a new window]   Figure 2. Frequency of individuals missing each tooth type.

View larger version (83K): [in a new window]   Figure 3. MSX1 mutation and sequence. (A) Lanes 3 and 4 show the band shift indicating SSCPs in the two initially identified siblings. Lanes 1, 2, 5, and 6 show unrelated individuals. (B) MSX1 sequence of unaffected individual; arrow indicates nucleotide 620, which matches published sequence (Hewitt et al., 1991). (C) MSX1 sequence of an affected heterozygous individual, with arrow indicating location of overlapping A and T peaks. (D) MSX1 sequence of DNA isolated from band shift. Arrows indicate mutated nucleotide.