|
Sign In to gain access to subscriptions and/or personal tools.
|
Journal of Dental Research, Vol. 81, No. 12,
817-821 (2002)
DOI: 10.1177/154405910208101204
Cementum: A Phosphate-sensitive Tissue
F.H. Nociti, Jr.1,2,*,
J.E. Berry1,
B.L. Foster5,
K.A. Gurley4,
D.M. Kingsley4,
T. Takata3,
M. Miyauchi3 and
M.J. Somerman1,5
1 Department of Periodontics/Prevention/Geriatrics, School of Dentistry, Rm. 3310M Dental, University of Michigan, 1011 N. University Avenue, Ann Arbor, MI 48109-1078, USA;
2 Department of Prosthodontics/Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, University of Campinas, Brazil;
3 Department of Oral Pathology, Faculty of Dentistry, Hiroshima University, Japan;
4 Department of Developmental Biology and Howard Hughes Medical Institute, School of Medicine, Stanford University, CA, USA;
5 Department of Periodontics, School of Dentistry, University of Washington, Seattle, USA;
View larger version (133K):
[in this window]
[in a new window]
|
Figure 1. Histological aspects of developing teeth at different stages (days 28, 35, and 45) from wild-type (WT) and ank mutant mice (MUT). A thicker layer of cementum was observed from day 28 (arrows), while the bone (B) and periodontal ligament region (P) appeared similar between WT and MUT mice. The difference in the cementum formation between WT and MUT was more evident at day 35 (arrows). By day 45, cementum thickness in MUT mice (*) was markedly increased compared with that in WT mice, indicating the increasingly divergent rates of cementogenesis between the two. In contrast, the PDL region, alveolar bone, and dentin (D) appeared similar between WT and MUT mice. (40X, bar = 100 µm).
|
|
View larger version (57K):
[in this window]
[in a new window]
|
Figure 2. At later stages, the PC-1 and ank mutant mice (days 77 and 52, respectively) showed histological similarities in alveolar bone (B), the periodontal ligament region (P), and cementum (*). Cementum appeared to be predominantly cellular, and markedly thicker than in wild-type mice. (20X, bar = 200 µm).
|
|
View larger version (34K):
[in this window]
[in a new window]
|
Figure 3. Proposed model for cementum formation: control of PPi/Pi locally is critical for development of a functional periodontium. An increased ratio of PPi/Pi results in minimal cementum (cem) formation, and exfoliation of teeth in humans. In contrast, lack of PPi, e.g., ank and PC-1 mutant mice, appears to favor cementum formation with normal development of the PDL region and bone.
|
|
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
|
|
