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Figure 1. Robust dental fluorosis seen in the A/J strain. Shown are representative A/J and 129P3/J mice after 60 days of treatment (0 ppm, 25 ppm, or 50 ppm fluoride as NaF in the drinking water). Upper and lower incisors of the A/J mice show dramatic color and character changes in response to fluoride. The diffuse yellow-orange color present in the teeth at 0 ppm is typical of normal tooth color development in A/J and other mice. In the 0 ppm treatment group, the lower incisors are translucent as judged by the passing of a periodontal probe behind the teeth. That translucency is not detectable at 25 ppm and 50 ppm [F]. Also in the A/J mice, the labial surfaces of the lower incisors became rough and pitted. At sites where there is a transition (distal aspects), ledges can be detected with probing. The 129P3/J strain is resistant to the development of dental fluorosis. Clinical changes in tooth color and opacity are seen only at the 50-ppm treatment level and are greatly reduced compared with those in A/J mice.
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