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Immunolocalization of PTCH Protein in Odontogenic Cysts and Tumors

¹ Departmento de Clínica, Patologia e Cirurgia, and
² Pharmacology, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Belo Horizonte-MG, Brazil CEP 31270-901;
³ Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA;

View larger version (160K): [in a new window]   Figure 1. Positive PTCH staining in intermediate and superficial layers of radicular cyst (A), odontogenic keratocyst (B), glandular odontogenic cyst (C), and dentigerous cyst (D). Note positive immunostaining of the hyaline bodies.

View larger version (169K): [in a new window]   Figure 2. Positive PTCH staining in central polyhedral and loosely connected angular cells of ameloblastoma (A) and mesenchymal cells of odontogenic myxoma (B). Fragment of normal oral mucosa shows weak immuno-positivity in the epithelium (C). While the epidermis overlying the basal cell carcinoma presented a strong PTCH staining, the vast majority of neoplastic cells were negative for PTCH (D).