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Mechanisms of Tooth Eruption and Orthodontic Tooth Movement

¹ Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA; and
² Department of Orthodontics, School of Dentistry, University of Washington, Seattle, WA 98195, USA

^* corresponding author, gwise{at}vetmed.lsu.edu

Teeth move through alveolar bone, whether through the normal process of tooth eruption or by strains generated by orthodontic appliances. Both eruption and orthodontics accomplish this feat through similar fundamental biological processes, osteoclastogenesis and osteogenesis, but there are differences that make their mechanisms unique. A better appreciation of the molecular and cellular events that regulate osteoclastogenesis and osteogenesis in eruption and orthodontics is not only central to our understanding of how these processes occur, but also is needed for ultimate development of the means to control them. Possible future studies in these areas are also discussed, with particular emphasis on translation of fundamental knowledge to improve dental treatments.

KEY WORDS: dental follicle • periodontal ligament • osteoclastogenesis • osteogenesis • RANKL • OPG • CSF-1 • bone remodeling • bone formation • bone resorption