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Effects of IL-17 on Human Gingival Fibroblasts

¹ Department of Periodontology,
² Research Unit for Periodontal Disease,
³ Immunology Laboratory, and
⁴ Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Henri Dunant Rd., Bangkok 10330, Thailand; and
⁵ Department of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand

^* corresponding author, mrangsin{at}chula.ac.th

Interleukin (IL)-17 is present in inflammatory periodontal lesions, thus suggesting a role in mediating inflammation. We tested the hypothesis that IL-17, especially when combined with interferon (IFN)-, may modulate the responses of human gingival fibroblasts (HGFs). IL-17 induced IL-8 and minimal intercellular adhesion molecule (ICAM)-1 expression. It had no effect on expression of HLA-DR, CD40, or the immune-suppressive enzyme indoleamine 2,3-dioxygenase (IDO). The effects of IL-17 on HGFs were compared with those of IFN-. Unlike IL-17, IFN- augmented the expression of HLA-DR, ICAM-1, and IDO, but not IL-8. Thus, IL-17 and IFN- induce different HGF responses when administered separately. Interestingly, when IL-17 and IFN- were combined, marked enhancement of ICAM-1, IL-8, and IDO expression by HGFs was observed. These findings suggest that IL-17, especially when combined with IFN-, could play an important role in immune modulation through stimulation of HGFs in periodontal disease.

KEY WORDS: human gingival fibroblasts • IL-17 • IFN- • IL-8 • IDO

Abbreviations: Interleukin (IL) • T-helper (Th) • human gingival fibroblasts (HGFs) • indoleamine 2,3-dioxygenase (IDO) • monoclonal antibodies (mAbs) • intercellular adhesion molecule (ICAM)-1 • interferon (IFN)- • tumor necrosis factor (TNF)- • mean fluorescence intensity (MFI)