JDR JDR Most Cited Articles
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Appendix
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Carrouel, F.
Right arrow Articles by Bleicher, F.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carrouel, F.
Right arrow Articles by Bleicher, F.
J Dent Res 87(2):131-136, 2008
© 2008 International and American Associations for Dental Research

RESEARCH REPORT
Biological

HUGO (FNDC3A): a New Gene Overexpressed in Human Odontoblasts

F. Carrouel1,2,3,4,5,6, M.-L. Couble1,2,3,4,5,6, C. Vanbelle1,7, M.-J. Staquet1,2,3,4,5,6, H. Magloire1,2,3,4,5,6, and F. Bleicher1,2,3,4,5,6,*

1 Université de Lyon, Villeurbanne, F-69000, France;
2 Université Lyon 1, Faculté d’Odontologie, Lyon, F-69008, France;
3 CNRS, UMR 5242, IGFL, Lyon, F-69007, France;
4 INRA, UMR 1288, Lyon, F-69007, France;
5 ENSL, Lyon, F-69007, France;
6 INSERM, ERI 16, Lyon, F-69008, France; and
7 Université Lyon 1, CeCIL, IFR62, Lyon, F-69008, France

* corresponding author, IGFL/INSERM ERI 16, Faculté d’Odontologie, Rue Guillaume Paradin, 69372 LYON Cedex 08, France, bleicher{at}univ-lyon1.fr

Previously, we established a subtractive cDNA library enriched in odontoblast-specific genes and hypothesized that new, previously unidentified, markers would be present, associated with the odontoblast phenotype. In this paper, we report the first characterization of a new gene we have named HUGO, and its associated deduced protein sequence. This gene expression is under the control of two alternative promoters, resulting in the synthesis of two proteins, one of which, HUGO2, is included in the other, HUGO1. HUGO proteins are mainly composed of a proline-rich region at the N-terminus, 8 type III-fibronectin modules, and a transmembranous helix at the C-terminus. In odontoblasts, the proteins are located in Golgi vesicles. However, they display a broader expression pattern, since they are also expressed by nerve fibers in the dental pulp and other tissues (e.g., trachea, brain, kidney), as demonstrated by immunohistochemistry and qPCR, respectively. Their location in odontoblasts suggests a role in collagen and glycosaminoglycan synthesis.

KEY WORDS: tooth • human odontoblast • new gene • type III-Fibronectin module • HUGO






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
Copyright © 2008 Institutional Access Guidelines