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Journal of Dental Research, Vol. 87, No. 11, 1048-1052 (2008)
DOI: 10.1177/154405910808701107

Biomaterials & Bioengineering

The Influence of Barrier Membranes on Autologous Bone Grafts

P.F.M. Gielkens1,*, J. Schortinghuis1, J.R. de Jong2, A.M.J. Paans2, J.L. Ruben3, G.M. Raghoebar1, B. Stegenga1 and R.R.M. Bos1

1 Department of Oral and Maxillofacial Surgery,
2 Department of Nuclear Medicine and Molecular Imaging, and
3 Department of Dentistry and Dental Hygiene, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands

Correspondence: * corresponding author, p.f.m.gielkens{at}kchir.umcg.nl

In implant dentistry, there is continuing debate regarding whether a barrier membrane should be applied to cover autologous bone grafts in jaw augmentation. A membrane would prevent graft remodeling with resorption and enhance graft incorporation. We hypothesized that membrane coverage does not effect resorption and incorporation of autologous onlay bone grafts. We treated 192 male Sprague-Dawley rats. A 4.0-mm-diameter bone graft was harvested from the right mandibular angle and transplanted to the left. Poly(DL-lactide-{varepsilon}-caprolactone), collagen, and expanded polytetrafluoroethylene membranes were used to cover the grafts. The controls were left uncovered. Graft resorption at 2, 4, and 12 weeks was evaluated by post mortem microradiography and microCT. Analysis of the data showed no significant differences among the 4 groups. This demonstrates that the indication of barrier membrane use, to prevent bone remodeling with resorption and to enhance incorporation of autologous onlay bone grafts, is at least disputable.

Key Words: Bone resorption • bone transplantation • membrane, artificial • microradiography • micro-CT


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