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Journal of Dental Research, Vol. 87, No. 11, 1032-1036 (2008)
DOI: 10.1177/154405910808701105

Clinical

Fluoride Release from CaF2 and Enamel Demineralization

L.M.A. Tenuta*, R.V. Cerezetti, A.A. Del Bel Cury, C.P.M. Tabchoury and J.A. Cury

Piracicaba Dental School, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP Piracicaba, SP, Brazil

Correspondence: * corresponding author, litenuta{at}fop.unicamp.br

The anticaries effect of professional fluoride (F) application has been attributed to calcium-fluoride-like deposits (CaF2) formed on enamel, but this has not been clearly demonstrated. We hypothesized that CaF2 formed on plaque-free enamel by F application would reduce enamel demineralization due to the increase of F availability in fluid of subsequently formed plaque. We created distinct levels of CaF2 on enamel to evaluate a dose-response effect. Enamel blocks were mounted in contact with a S. mutans test plaque and used in situ by 10 volunteers. F released to the fluid phase of this substrate ("plaque fluid") was measured before a cariogenic challenge. "Plaque fluid" F concentration was highly correlated to the enamel CaF2 concentration (r = 0.96, p < 0.001) and to consequent enamel demineralization (r = –0.75, p < 0.001). The results suggest that F released to plaque fluid from CaF2 formed on enamel may play a significant role in the anticaries effect of professionally applied F agents.

Key Words: fluoride • topical application • plaque fluid • demineralization • calcium fluoride


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