HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zuo, J. Articles by Dolce, C. Search for Related Content PubMed PubMed Citation Articles by Zuo, J. Articles by Dolce, C.

Nuclear Factor B p65 Phosphorylation in Orthodontic Tooth Movement

Department of Orthodontics, 1600 SW Archer Road, Campus Box 100444, University of Florida College of Dentistry, Gainesville, FL 32610, USA

^* corresponding author, cdolce{at}dental.ufl.edu

Osteoclasts play a vital role in orthodontic tooth movement. Transactivation of nuclear factor B (NFB) by phosphorylation of the p65 component of NFB at amino acid 536 (p65*⁵³⁶) plays a role in osteoclast differentiation stimulated by receptor activator of nuclear factor B-ligand (RANK-L). We hypothesized that this transactivation pathway might be involved in the responses of alveolar bone cells during orthodontic tooth movement. We detected sharp increases in the levels of p65*⁵³⁶ 3 and 12 hrs after the application of orthodontic stimuli in rats. In cell culture, osteoclast-like cells displayed no changes in p65*⁵³⁶ in response to RANK-L, but levels rapidly increased after the cells were mechanically scraped. We conclude that p65*⁵³⁶ is produced rapidly in response to orthodontic stimuli and mechanical insults, and may be important in bone remodeling associated with orthodontic tooth movement.

KEY WORDS: osteoclast • bone resorption • RANK • RAW 264.7 • osteoclastogenesis