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Tissue-engineered Oral Mucosa: a Review of the Scientific Literature

¹ School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, United Kingdom; and
² Department of Engineering Materials, University of Sheffield, Broad Lane, Sheffield, S3 7HQ, United Kingdom

^* corresponding author, k.moharamzadeh{at}sheffield.ac.uk

Tissue-engineered oral mucosal equivalents have been developed for clinical applications and also for in vitro studies of biocompatibility, mucosal irritation, disease, and other basic oral biology phenomena. This paper reviews different tissue-engineering strategies used for the production of human oral mucosal equivalents, their relative advantages and drawbacks, and their applications. Techniques used for skin tissue engineering that may possibly be used for in vitro reconstruction of human oral mucosa are also discussed.

KEY WORDS: oral mucosa • tissue engineering • scaffold • keratinocyte

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