| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
RESEARCH REPORT |
1 Australian Research Centre for Population Oral Health, Dental School, University of Adelaide, SA 5005, Australia;
2 University of North Carolina, Chapel Hill, USA;
3 Chulalongkorn University, Bangkok, Thailand;
4 Public Health Services and Research, University of Florida College of Dentistry, Gainesville, USA;
5 NIDCR, NIH, DHHS, Bethesda, MD, USA; and
6 NIAAA, NIH, DHHS, Rockville, MD, USA
* corresponding author, gary.slade{at}adelaide.edu.au
Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would influence risk of first-onset TMD, but the effect could be attributed to variation in the gene encoding catechol-O-methyltransferase (COMT). We undertook a prospective cohort study of healthy female volunteers aged 18–34 yrs. At baseline, participants were genotyped, they completed psychological questionnaires, and underwent quantitative sensory testing to determine pain sensitivity. We followed 171 participants for up to three years, and 8.8% of them were diagnosed with first-onset TMD. Depression, perceived stress, and mood were associated with pain sensitivity and were predictive of 2- to 3-fold increases in risk of TMD (P < 0.05). However, the magnitude of increased TMD risk due to psychological factors remained unchanged after adjustment for the COMT haplotype. Psychological factors linked to pain sensitivity influenced TMD risk independently of the effects of the COMT haplotype on TMD risk.
KEY WORDS: temporomandibular joint disorders • cohort studies • psychology • catechol O-methyltransferase • genetics
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| IADR Journals | Advances in Dental Research ® |
| Journal of Dental Research ® | Critical Reviews (1990-2004) |
