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Chlorhexidine Preserves Dentin Bond in vitro

¹ Department of Restorative Dentistry, Dental Materials, Piracicaba School of Dentistry, University of Campinas, Piracicaba, SP, Brazil;
² Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil;
³ Dows Institute for Dental Research and Department of Operative Dentistry, University of Iowa, Iowa City, USA;
⁴ Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA, USA; and
⁵ Institute of Dentistry, University of Helsinki, PO Box 41, 00014 University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland

^* corresponding author, leo.tjaderhane{at}helsinki.fi

Loss of hybrid layer integrity compromises resin-dentin bond stability. Matrix metalloproteinases (MMPs) may be partially responsible for hybrid layer degradation. Since chlorhexidine inhibits MMPs, we hypothesized that chlorhexidine would decelerate the loss of resin-dentin bonds. Class I preparations in extracted third molars were sectioned into two halves. One half was customarily restored (etch-and-rinse adhesive/resin composite), and the other was treated with 2% chlorhexidine after being acid-etched before restoration. Specimens were stored in artificial saliva with/without protease inhibitors. Microtensile bond strengths and failure mode distribution under SEM were analyzed immediately after specimens’ preparation and 6 months later. With chlorhexidine, significantly better preservation of bond strength was observed after 6 months; protease inhibitors in the storage medium had no effect. Failure analysis showed significantly less failure in the hybrid layer with chlorhexidine, compared with controls after 6 months. In conclusion, this in vitro study suggests that chlorhexidine might be useful for the preservation of dentin bond strength.

KEY WORDS: matrix metalloproteinase • hybrid layer • tooth • microtensile • adhesive

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				M.R.O. Carrilho, S. Geraldeli, F. Tay, M.F. de Goes, R.M. Carvalho, L. Tjaderhane, A.F. Reis, J. Hebling, A. Mazzoni, L. Breschi, et al. In vivo Preservation of the Hybrid Layer by Chlorhexidine J. Dent. Res., June 1, 2007; 86(6): 529 - 533. [Abstract] [Full Text] [PDF]