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J Dent Res 85(6):557-559, 2006
© 2006 International and American Associations for Dental Research

RESEARCH REPORT
Clinical

A Two-year Randomized Clinical Trial of Chlorhexidine Varnish on Dental Caries in Chinese Preschool Children

M.Q. Du1, B.J. Tai1, H. Jiang1, E.C.M. Lo2, M.W. Fan3,*, and Z. Bian3,*

1 Department of Preventive Dentistry, School of Stomatology, Wuhan University, Hubei, China;
2 Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China; and
3 Key Lab for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Hubei, China

* corresponding authors, kqyywjtx{at}public.wh.hb.cn, fmwbgsh{at}sina.com.cnhbcoh{at}public.wh.hb.cn

The objective of this study was to assess the effect of six-monthly professional applications of chlorhexidine varnish on the prevention of dental caries in primary molars in Chinese preschool children. In a double-blinded, randomized, placebo-controlled clinical trial, 334 children aged 4–5 years were randomly divided into two groups. Children in the test group received six-monthly applications of a 40% chlorhexidine varnish, and the control children received a placebo varnish. Caries status of the children was assessed by two calibrated examiners at baseline and after 24 months, according to criteria recommended by the World Health Organization. The two-year mean caries increments in the test and the control group children were 1.0 and 1.6 decayed, missing, or filled molar surfaces (dmfs-molar), respectively, a 37.3% reduction (t test, p = 0.036). No side-effects were found. It was concluded that six-monthly applications of chlorhexidine varnish were effective in reducing the incidence of dental caries in primary molars.

KEY WORDS: clinical trial • chlorhexidine varnish • caries prevention • primary teeth






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