HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Andrian, E. Articles by Rouabhia, M. Search for Related Content PubMed PubMed Citation Articles by Andrian, E. Articles by Rouabhia, M.

Porphyromonas gingivalis-Epithelial Cell Interactions in Periodontitis

Groupe de Recherche en Écologie Buccale, Faculté de médecine dentaire, Université Laval, Quebec City, Quebec, Canada, G1K 7P4

^* corresponding author, Daniel.Grenier{at}greb.ulaval.ca

Emerging data on the consequences of the interactions between invasive oral bacteria and host cells have provided new insights into the pathogenesis of periodontal disease. Indeed, modulation of the mucosal epithelial barrier by pathogenic bacteria appears to be a critical step in the initiation and progression of periodontal disease. Periodontopathogens such as Porphyromonas gingivalis have developed different strategies to perturb the structural and functional integrity of the gingival epithelium. P. gingivalis adheres to, invades, and replicates within human epithelial cells. Adhesion of P. gingivalis to host cells is multimodal and involves the interaction of bacterial cell-surface adhesins with receptors expressed on the surfaces of epithelial cells. Internalization of P. gingivalis within host cells is rapid and requires both bacterial contact-dependent components and host-induced signaling pathways. P. gingivalis also subverts host responses to bacterial challenges by inactivating immune cells and molecules and by activating host processes leading to tissue destruction. The adaptive ability of these pathogens that allows them to survive within host cells and degrade periodontal tissue constituents may contribute to the initiation and progression of periodontitis. In this paper, we review current knowledge on the molecular cross-talk between P. gingivalis and gingival epithelial cells in the development of periodontitis.

KEY WORDS: periodontitis • epithelial cell • Porphyromonas gingivalis • adhesion • invasion

This article has been cited by other articles:

				S.-i. Nishiyama, Y. Murakami, H. Nagata, S. Shizukuishi, I. Kawagishi, and F. Yoshimura Involvement of minor components associated with the FimA fimbriae of Porphyromonas gingivalis in adhesive functions Microbiology, June 1, 2007; 153(6): 1916 - 1925. [Abstract] [Full Text] [PDF]

				M. A. Eskan, G. Hajishengallis, and D. F. Kinane Differential Activation of Human Gingival Epithelial Cells and Monocytes by Porphyromonas gingivalis Fimbriae Infect. Immun., February 1, 2007; 75(2): 892 - 898. [Abstract] [Full Text] [PDF]