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Effects of Phenylephrine on Transplanted Submandibular Gland

¹ Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Zhong Guan Cun South St. 22, 100081, Beijing, PRC;
² Department of Physiology and Pathophysiology, Peking University Health Science Center, 100083, Beijing;
³ Dalian Medical University School of Stomatology, 116011, Dalian; and
⁴ Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, 100083, Beijing

^* co-corresponding authors, gyyu{at}263.net and pathophy{at}bjmu.edu.cn

Autotransplantation of the submandibular gland is a potential treatment for severe kerato-conjunctivitis sicca. However, one of the major barriers to this procedure is that secretions from the transplanted gland decrease shortly after the operation, which may lead to obstruction of Wharton’s duct, or even to transplantation failure. Using a rabbit model, we investigated whether phenylephrine could improve the secretion from the transplanted gland. We found that phenylephrine treatment significantly reversed the decrease in salivary secretion after transplantation, enhanced the expressions of _1A-, _1B-, and _1D-adrenoceptor mRNA, and ameliorated atrophy of acinar cells. Furthermore, phenylephrine also induced translocation of aquaporin-5 from the cytoplasm to the apical membrane, and increased the levels of phospho-ERK1/2, ERK1/2, phospho-PKC, and PKC in the transplanted gland. These results indicate that phenylephrine treatment moderates structural injury and improves secretory function in the transplanted submandibular gland through promoting ₁-adrenoceptor expression and post-receptor signal transduction.

KEY WORDS: submandibular gland auto-transplantation • ₁-adrenoceptor • phenylephrine