HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Ohazama, A. Articles by Sharpe, P.T. Search for Related Content PubMed PubMed Citation Articles by Ohazama, A. Articles by Sharpe, P.T.

Organized Tooth-specific Cellular Differentiation Stimulated by BMP4

Department of Craniofacial Development, Dental Institute, Kings College London, Floor 28 Guy’s Hospital, London Bridge, London SE1 9RT, UK;

^* corresponding author, paul.sharpe{at}kcl.ac.uk

Mammalian teeth develop on the oral surface of the first pharyngeal arch by a series of reciprocal interactions between epithelial and mesenchymal cells. The embryonic first pharyngeal arch oral epithelium is able to induce tooth formation when combined with mesenchymal cells from the second pharyngeal arch, a region devoid of tooth development. Second pharyngeal arch mesenchyme is thus competent to form teeth if provided with the correct signals. First-arch oral epithelium expresses several signaling molecules that could be potential inducers of tooth development, including BMP4. The addition of BMP4 to intact second-arch explants resulted in the development of organized structures containing layers of cells that express marker genes of tooth-specific cells, odontoblasts and ameloblasts. Thus, although overt tooth development did not occur, BMP4 has the ability to stimulate organized differentiation of epithelial- and mesenchymal-derived dental-specific cells from non-dental primordia.

KEY WORDS: 2nd pharyngeal arch • tooth development • epithelium • mesenchyme • tissue engineering

This article has been cited by other articles:

				D. J. Mahoney, K. Mikecz, T. Ali, G. Mabilleau, D. Benayahu, A. Plaas, C. M. Milner, A. J. Day, and A. Sabokbar TSG-6 Regulates Bone Remodeling through Inhibition of Osteoblastogenesis and Osteoclast Activation J. Biol. Chem., September 19, 2008; 283(38): 25952 - 25962. [Abstract] [Full Text] [PDF]