HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) An erratum has been published Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Sharma, A. Articles by Evans, R.T. Search for Related Content PubMed PubMed Citation Articles by Sharma, A. Articles by Evans, R.T.

Tannerella forsythia-induced Alveolar Bone Loss in Mice Involves Leucine-rich-repeat BspA Protein

¹ Department of Oral Biology, School of Dental Medicine, State University of New York, 3435 Main Street, Buffalo, NY 14214, USA;
² Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba 261-8502, Japan; and
³ Department of Biology, Bates College, Lewiston, ME 04240, USA;

^* corresponding author, sharmaa{at}buffalo.edu

Tannerella forsythia (formerly Bacteroides forsythus) is one of the periodontal pathogens recently implicated in the development of periodontal disease. The cell-surface-associated, as well as the secreted, leucine-rich-repeat protein (BspA) of this bacterium have been suggested to play roles in bacterial adherence, and also in inflammation, by triggering release of pro-inflammatory cytokines from monocytes and chemokines from osteoblasts, leading to inflammation and bone resorption. In this study, we sought to determine the pathogenic potential of T. forsythia and the in vivo role of the BspA protein in pathogenesis in the mouse model of infection-induced alveolar bone loss. The results showed alveolar bone loss in mice infected with the T. forsythia wild-type strain, whereas the BspA mutant was impaired. In conclusion, evidence is presented in support of T. forsythia as an important organism involved in inducing alveolar bone loss, and the BspA protein is an important virulence factor of this bacterium.

KEY WORDS: Tannerella forsythia • alveolar bone loss • BspA protein • leucine-rich-repeat protein

This article has been cited by other articles:

				S. Onishi, K. Honma, S. Liang, P. Stathopoulou, D. Kinane, G. Hajishengallis, and A. Sharma Toll-Like Receptor 2-Mediated Interleukin-8 Expression in Gingival Epithelial Cells by the Tannerella forsythia Leucine-Rich Repeat Protein BspA Infect. Immun., January 1, 2008; 76(1): 198 - 205. [Abstract] [Full Text] [PDF]

				L. Kesavalu, S. Sathishkumar, V. Bakthavatchalu, C. Matthews, D. Dawson, M. Steffen, and J. L. Ebersole Rat Model of Polymicrobial Infection, Immunity, and Alveolar Bone Resorption in Periodontal Disease Infect. Immun., April 1, 2007; 75(4): 1704 - 1712. [Abstract] [Full Text] [PDF]

				J. Sakakibara, K. Nagano, Y. Murakami, N. Higuchi, H. Nakamura, K. Shimozato, and F. Yoshimura Loss of adherence ability to human gingival epithelial cells in S-layer protein-deficient mutants of Tannerella forsythensis Microbiology, March 1, 2007; 153(3): 866 - 876. [Abstract] [Full Text] [PDF]

				S. Inagaki, S. Onishi, H. K. Kuramitsu, and A. Sharma Porphyromonas gingivalis Vesicles Enhance Attachment, and the Leucine-Rich Repeat BspA Protein Is Required for Invasion of Epithelial Cells by "Tannerella forsythia" Infect. Immun., September 1, 2006; 74(9): 5023 - 5028. [Abstract] [Full Text] [PDF]