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Bio-adhesive Surfaces to Promote Osteoblast Differentiation and Bone Formation

Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, 2314 Petit Biotechnology Building, Atlanta, GA 30332-0363, USA;

^* corresponding author, andres.garcia{at}me.gatech.edu

Binding of integrin adhesion receptors to extracellular matrix components, such as fibronectin and type I collagen, activates signaling pathways directing osteoblast survival, cell-cycle progression, gene expression, and matrix mineralization. Biomimetic strategies exploit these adhesive interactions to engineer bio-inspired surfaces that promote osteoblast adhesion and differentiation, bone formation, and osseointegration. These emerging initiatives focus on directing integrin binding through presentation of bio-adhesive motifs derived from extracellular matrices. These biomolecular approaches provide promising strategies for the development of biologically active implants and grafting substrates for enhanced bone repair.

KEY WORDS: integrin • fibronectin • RGD • type I collagen • GFOGER • cell adhesion • biomaterial